role of visible light-activated photocatalyst on the reduction of anthrax spore-induced mortality in mice可见光控光催化剂的作用在老鼠炭疽spore-induced死亡率的降低.pdfVIP

Role of Visible Light-Activated Photocatalyst on the Reduction of Anthrax Spore-Induced Mortality in Mice 1. 2,3. 1 4 1 Jyh-Hwa Kau , Der-Shan Sun , Hsin-Hsien Huang , Ming-Show Wong , Hung-Chi Lin , Hsin-Hou Chang2,3* 1 Institute of Preventive Medicine, National Defense Medical Center, Taipei, Taiwan, 2 Institute of Molecular Biology and Human Genetics, Tzu-Chi University, Hualien, Taiwan, 3 Institute of Medical Science, Tzu-Chi University, Hualien, Taiwan, 4 Department of Materials Science and Engineering, National Dong-Hwa University, Hualien, Taiwan, Republic of China Abstract Background: Photocatalysis of titanium dioxide (TiO ) substrates is primarily induced by ultraviolet light irradiation. Anion- 2 doped TiO2 substrates were shown to exhibit photocatalytic activities under visible-light illumination, relative environmentally-friendly materials. Their anti-spore activity against Bacillus anthracis, however, remains to be investigated. We evaluated these visible-light activated photocatalysts on the reduction of anthrax spore-induced pathogenesis. Methodology/Principal Findings: Standard plating method was used to determine the inactivation of anthrax spore by visible light-induced photocatalysis. Mouse models were further employed to investigate the suppressive effects of the photocatalysis on anthrax toxin- and spore-mediated mortality. We found that anti-spore activities of visible light illuminated nitrogen- or carbon-doped titania thin films significantly reduced viability of anthrax spores. Even though the spore-killing efficiency is only approximately 2