risk factor analyses for immune reconstitution inflammatory syndrome in a randomized study of early vs. deferred art during an opportunistic infection风险因素分析免疫重建炎性综合症的早期和延迟的随机研究艺术在机会性感染.pdfVIP
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risk factor analyses for immune reconstitution inflammatory syndrome in a randomized study of early vs. deferred art during an opportunistic infection风险因素分析免疫重建炎性综合症的早期和延迟的随机研究艺术在机会性感染
Risk Factor Analyses for Immune Reconstitution
Inflammatory Syndrome in a Randomized Study of Early
vs. Deferred ART during an Opportunistic Infection
1 2 2 3 4
Philip M. Grant *, Lauren Komarow , Janet Andersen , Irini Sereti , Savita Pahwa , Michael M.
5 6 7 8 9 10
Lederman , Joseph Eron , Ian Sanne , William Powderly , Evelyn Hogg , Carol Suckow , Andrew
Zolopa1
1 Stanford University, Palo Alto, California, United States of America, 2 Statistical and Data Analysis Center, Harvard School of Public Health, Boston, Massachusetts, United
States of America, 3 National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, 4 University of
Miami, Miami, Florida, United States of America, 5 Case Western University, Cleveland, Ohio, United States of America, 6 University of North Carolina, Chapel Hill, North
Carolina, United States of America, 7 Wits Health Consortium, Helen Joseph Hospital, Johannesburg, South Africa, 8 University College Dublin, Dublin, Ireland, 9 Social and
Scientific Systems, Incorporated, Silver Spring, Maryland, United States of America, 10 Frontier Science and Technology Research Foundation, Amherst, New York, United
States of America
Abstract
Background: Immune reconstitution inflammatory syndrome (IRIS) is reported widely in patients initiating antiretroviral
therapy (ART). However, few studies are prospective, and no study has evaluated the impact of the timing of ART when
allocated randomly during an acute opportunistic infection (OI).
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