原创力文档risk factors for treatment default among re-treatment tuberculosis patients in india, 2006其违约风险因素治疗肺结核患者在印度,2006人.pdfVIP
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risk factors for treatment default among re-treatment tuberculosis patients in india, 2006其违约风险因素治疗肺结核患者在印度,2006人
Risk Factors for Treatment Default among Re-Treatment
Tuberculosis Patients in India, 2006
1 2 3 3 3
Ugra Mohan Jha , Srinath Satyanarayana *, Puneet K. Dewan , Sarabjit Chadha , Fraser Wares ,
3 1 1
Suvanand Sahu , Devesh Gupta , L. S. Chauhan
1 Central Tuberculosis Division, Directorate General of Health Services, Ministry of Health and Family Welfare, Government of India, New Delhi, India, 2 Centre for
Operational Research, International Union Against Tuberculosis and Lung Diseases (The Union), New Delhi, India, 3 Office of the WHO Representative to India, New Delhi,
India
Abstract
Setting: Under India’s Revised National Tuberculosis Control Programme (RNTCP), .15% of previously-treated patients in
the reported 2006 patient cohort defaulted from anti-tuberculosis treatment.
Objective: To assess the timing, characteristics, and risk factors for default amongst re-treatment TB patients.
Methodology: For this case-control study, in 90 randomly-selected programme units treatment records were abstracted
from all 2006 defaulters from the RNTCP re-treatment regimen (cases), with one consecutively-selected non-defaulter per
case. Patients who interrupted anti-tuberculosis treatment for .2 months were classified as defaulters.
Results: 1,141 defaulters and 1,189 non-defaulters were included. The median duration of treatment prior to default was 81
days (25%–75% interquartile range 44–117 days) and documented retrieval efforts after treatment interruption were
inadequate. Defaulters were more likely to have been male (adjusted odds ratio [aOR] 1.4, 95% confidence interval [CI] 1.2–
1.7), have previously defaulted anti-tuberculosis treat
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