原创力文档response of high-sensitive c-reactive protein to catheter ablation of atrial fibrillation and its relation with rhythm outcome高灵敏度c反应蛋白的反应房颤导管消融,与节奏的关系的结果.pdfVIP
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response of high-sensitive c-reactive protein to catheter ablation of atrial fibrillation and its relation with rhythm outcome高灵敏度c反应蛋白的反应房颤导管消融,与节奏的关系的结果
Response of High-Sensitive C-Reactive Protein to
Catheter Ablation of Atrial Fibrillation and Its Relation
with Rhythm Outcome
1 2 1 1 1 2
Jelena Kornej *, Claudia Reinhardt , Jedrzej Kosiuk , Arash Arya , Gerhard Hindricks , Volker Adams ,
Daniela Husser1, Andreas Bollmann1
1 Department of Electrophysiology, Heart Center, Leipzig, Leipzig, Germany, 2 Department of Cardiology, Heart Center, Leipzig, Leipzig, Germany
Abstract
Aims: This study investigated the possible association between hs-CRP as well as hs-CRP changes and rhythm outcome after
AF catheter ablation.
Methods: We studied 68 consecutive patients with AF undergoing catheter ablation. hs-CRP levels were measured using
commercially available assays before and 6 months after catheter ablation. Serial 7-day Holter ECGs were used to detect AF
recurrences.
Results: Early AF recurrence (ERAF, within one week) was observed in 38%, while late AF recurrence (LRAF, between 3 and 6
months) occurred in 18% of the patients. None of the baseline clinical or echocardiographic variables was predictive of ERAF
or LRAF. Baseline hs-CRP measured 2.07 61.1 mg/ml and was not associated with ERAF and LRAF. At 6 months, hs-CRP levels
were comparable with baseline values (2.14 61.19 mg/ml, p = 0.409) and were also not related with LRAF. However, patients
with LRAF showed an hs-CRP increase from 2.03 60.61 to 2.62 61.52 mg/ml (p = 0.028). Patients with an hs-CRP change in
the upper tertile (.0.2 mg/ml) had LRAF in 32% as opposed to 11% (p = 0.042) in patients in the lower (,20.3 mg/ml) or
intermediate (20.3–0.2 mg/ml) tertile.
Conclusions: Changes in hs-CRP but not baseline hs-CRP are associated with rhythm outcome after AF catheter ablation.
This finding points to a link between an in
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