relationship between neural alteration and perineural invasion in pancreatic cancer patients with hyperglycemia神经改变之间的关系,在胰腺癌患者高血糖神经周的入侵.pdfVIP

Relationship between Neural Alteration and Perineural Invasion in Pancreatic Cancer Patients with Hyperglycemia 1,2 1 1 1 1 1 1 3 3 Junhui Li , Qingyong Ma *, Han Liu , Kun Guo , Feng Li , Wei Li , Liang Han , Fengfei Wang , Erxi Wu * 1 Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an, Shaanxi, China, 2 Department of General Surgery, Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an, Shaanxi, China, 3 Department of Pharmaceutical Sciences, North Dakota State University, Fargo, North Dakota, United States of America Abstract Background: Patients with higher levels of fasting serum glucose have higher death rates from pancreatic cancer compared to patients with lower levels of fasting serum glucose. However, the reasons have not been studied. The goal of the current study was to examine the neural alterations in pancreatic cancer patients with hyperglycemia and to identify the relationship between the neural alterations and perineural invasion. Methodology/Principal Findings: The clinical and pathological features of 61 formalin-fixed pancreatic cancer specimens and 10 normal pancreases as controls were analyzed. Furthermore, the expression of Protein Gene Product 9.5 (PGP9.5), Myelin P0 protein (MPP), NGF, TrkA, and p75 were examined by immunohistochemistry. The median number of nerves, the median area of neural tissue, and the median nerve diameter per 10 mm2 were larger in the hyperglycemia group than those in the euglycemia group (p = 0.007, p = 0.009, and p = 0.004, respectively). The integrated optical density (IOD) of MPP staining was lower in the hyperglycemia group than those in the e