原创力文档relationship between the inflammatory molecular profile of breast carcinomas and distant metastasis development关系炎症分子的乳房癌和远处转移的发展.pdfVIP
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relationship between the inflammatory molecular profile of breast carcinomas and distant metastasis development关系炎症分子的乳房癌和远处转移的发展
Relationship between the Inflammatory Molecular
Profile of Breast Carcinomas and Distant Metastasis
Development
´ ´ 1. ´ ´ 1. ´ 1,2 1 1,3
Noemı Eiro , Lucıa Gonzalez , Luis O. Gonzalez , Belen Fernandez-Garcia , Maria Luz Lamelas ,
´ 1 ´ ´ 1 ´ 1,4 1,4
Laura Marın , Salome Gonzalez-Reyes , Jose Manuel del Casar , Francisco J. Vizoso *
´ ´ ´ ´ ´ ´ ´
1 Unidad de Investigacion, Fundacion Hospital de Jove, Gijon, Asturias, Spain, 2 Servicio de Anatomıa Patologica, Fundacion Hospital de Jove, Gijon, Asturias, Spain,
´ ´ ´ ´ ´ ´
3 Servicio de Ginecologıa, Fundacion Hospital de Jove, Gijon, Asturias, Spain, 4 Servicio de Cirugıa General, Fundacion Hospital de Jove, Gijon, Asturias, Spain
Abstract
Inflammatory conditions may promote tumor progression and aggressiveness. In previous reports, we found a group of
breast cancer tumors characterized by metalloprotease-11 (MMP-11) expression by intratumoral mononuclear inflammatory
cells (MICs), which was associated with distant metastasis development. Thus, in the present study we evaluated the
relationship between MMP-11 expression by MICs, distant metastasis development,
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