原创力文档relationships between levels of serum ige, cell-bound ige, and ige-receptors on peripheral blood cells in a pediatric population血清ige水平之间的关系,cell-bound ige,ige-receptors外周血细胞在儿科人口.pdfVIP
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relationships between levels of serum ige, cell-bound ige, and ige-receptors on peripheral blood cells in a pediatric population血清ige水平之间的关系,cell-bound ige,ige-receptors外周血细胞在儿科人口
Relationships between Levels of Serum IgE, Cell-Bound
IgE, and IgE-Receptors on Peripheral Blood Cells in a
Pediatric Population
1,2 1 1 1. 1 .
Eleonora Dehlink , Alexandra H. Baker , Elizabeth Yen , Samuel Nurko , Edda Fiebiger *
1 Division of Gastroenterology and Nutrition and EGID Centre, Children’s Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America,
2 Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Waehringer Guertel, Vienna, Austria
Abstract
Background: Elevated serum immunoglobulin (Ig) E is a diagnostic marker of immediate-type allergic reactions. We
hypothesize that serum IgE does not necessarily reflect total body IgE because in vivo IgE can be bound to cell surface
receptors such as FceRI and FceRII (CD23). The aim of this study was to analyze the relationships between levels of serum
IgE, cell-bound IgE, and IgE-receptors on peripheral blood cells in a pediatric population.
Methodology: Whole blood samples from 48 children (26 boys, 22 girls, mean age 10,3 65,4 years) were analyzed by flow
cytometry for FceRI, CD23, and cell-bound IgE on dendritic cells (CD11c+MHC class II+), monocytes (CD14+), basophils
(CD123+MHC class II-) and neutrophils (myeloperoxidase+). Total serum IgE was measured by ELISA and converted into z-
units to account for age-dependent normal ranges. Correlations were calculated using Spearman rank correlation test.
Principal Findings: Dendritic cells, monocytes, basophils, and neutrophils expressed the high affinity IgE-receptor FceRI.
Dendritic cells and monocytes also expressed the low affinity receptor CD23. The m
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