relationship between tnf- gene promoter polymorphisms and outcomes of hepatitis b virus infections a meta-analysis肿瘤坏死因子-基因启动子多态性之间的关系和乙型肝炎病毒感染一个荟萃分析的结果.pdfVIP

Relationship between TNF- ,alpha . Gene Promoter Polymorphisms and Outcomes of Hepatitis B Virus Infections: A Meta-Analysis 1 2 1 1 1 Qi Xia , LinFu Zhou , Dongcheng Liu , Zhi Chen , Feng Chen * 1 State Key Laboratory of Infectious Disease Diagnosis and Treatment, College of Medicine, First Affiliated Hospital, Zhejiang University, Zhejiang, China, 2 Department of Biochemistry, College of Medicine, Zhejiang University, Zhejiang, China Abstract Background: The clearance of hepatitis B virus (HBV) is a complex process which may be influenced by many factors including polymorphisms in the tumor necrosis factor ,alpha. (TNF-,alpha.) gene promoter. However, previous reports regarding the relationship between polymorphisms in the TNF-,alpha. promoter and HBV clearance have been inconsistent. Therefore, we performed a meta-analysis on a large population to address this inconsistency. Methods: A meta-analysis was performed to examine the association between TNF-,alpha. promoter polymorphisms (-1031T/C, -863C/A, -857C/T, -308G/A and-238G/A) and chronic hepatitis B infection. Odds ratio (OR) and its 95 % confidence interval (CI) were used. Results: Twelve studies were chosen in our meta-analysis, involving 2,754 chronic HBV infection cases and 1,630 HBV clearance cases. The data showed that TNF-,alpha.-863 CC genotype was significantly associated with HBV clearance (-863 CC vs. AA: OR, 0.64; 95% CI, [0.42, 0.97]; p = 0.04) while patients carrying -308 GG genotype had a significantly increased risk of HBV persistence compared with those with GA or AA genotype (GG vs. GA+AA: OR, 1.35; 95% CI, [1.08, 1.70]; p = 0.01). For the other polymorphisms, no association with HBV infection outc