relationships between specific airway resistance and forced expiratory flows in asthmatic children之间的关系具体气道阻力和哮喘儿童的用力呼气流量.pdfVIP

Relationships between Specific Airway Resistance and Forced Expiratory Flows in Asthmatic Children 1,2,3,7 4,5,7,8 2,4,6,7 3 Bruno Mahut , Ludovic Trinquart , Plamen Bokov , Muriel Le Bourgeois , Serge Waernessyckle3, Claudine Peiffer2,7, Christophe Delclaux2,4,7* ˆ ˆ ´ ´ 1 Cabinet La Berma, Antony, France, 2 Assistance Publique-Hopitaux de Paris, Hopital Europeen Georges Pompidou, Departement de Physiologie, Radio-Isotopes, Clinique ´ ˆ ˆ ´ de la Dyspnee, Paris, France, 3 Assistance Publique-Hopitaux de Paris, Hopital Necker Enfants-Malades, Service de Pneumo-Allergologie Pediatrique, Paris, France, ´ ˆ ˆ ´ ´ ´ 4 Universite Paris Descartes, Paris, France, 5 Assistance Publique-Hopitaux de Paris, Hopital Europeen Georges Pompido, Unite de Recherche Clinique et d’Epidemiologie, ` ` ´ Paris, France, 6 Laboratoire Matiere et Systemes Complexes (MSC); UMR 7057 CNRS Universite Paris Diderot, Paris, France, 7 Mosquito Respiratory Research Group, Paris, France, 8 INSERM CIE 4, Paris, France Abstract Background: The earliest changes associated with airflow obstruction in asthmatic children are a proportionally greater reduction in FEF50% than in FEV1 using spirometry, and an increase in specific airway resistance