relationships between body fat distribution, epicardial fat and obstructive sleep apnea in obese patients with and without metabolic syndrome身体脂肪分布之间的关系,心外膜脂肪和阻塞性睡眠呼吸暂停在肥胖患者,没有代谢综合征.pdfVIP

Relationships between Body Fat Distribution, Epicardial Fat and Obstructive Sleep Apnea in Obese Patients with and without Metabolic Syndrome 1 2 1 1 1 Carla Lubrano *, Maurizio Saponara , Giuseppe Barbaro , Palma Specchia , Eliana Addessi , 1 1 1 1 1 Daniela Costantini , Marta Tenuta , Gabriella Di Lorenzo , Giuseppe Genovesi , Lorenzo M. Donini , Andrea Lenzi1, Lucio Gnessi1 1 Department of Experimental Medicine, Section of Medical Physiopathology, Endocrinology and Food Science, University of Rome ‘‘Sapienza’’, Rome, Italy, 2 Head and Neck Department, University of Rome ‘‘Sapienza’’, Rome, Italy Abstract Background: Obstructive sleep apnea (OSA) and metabolic syndrome, both closely related to obesity, often coexist in affected individuals; however, body mass index is not an accurate indicator of body fat and thus is not a good predictor of OSA and other comorbidities. The aim of this study was to investigate whether the occurrence of OSA could be associated with an altered body fat distribution and a more evident cardio metabolic risk independently from obesity and metabolic syndrome. Methods and Results: 171 consecutive patients (58 men and 113 women) were included in the study and underwent overnight polysomnography. Anthropometric data, blood pressure, lipid profile, glycaemic parameters were recorded. Body composition by DXA, two-dimensional echocardiography and carotid intima/media thickness measurement were performed. 67 patients (39.2%) had no OSA and 104 (60.8%) had OSA. The percentage of patients w