respiratory dendritic cell subsets differ in their capacity to support the induction of virus-specific cytotoxic cd8+ t cell responses呼吸树突细胞有不同的子集的能力支持诱导特异性细胞毒性cd8 + t细胞的反应.pdfVIP

Respiratory Dendritic Cell Subsets Differ in Their Capacity to Support the Induction of Virus-Specific Cytotoxic CD8+ T Cell Responses 1 1,2 Taeg S. Kim , Thomas J. Braciale * 1 Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia, United States of America, 2 Departments of Microbiology and Pathology, University of Virginia, Charlottesville, Virginia, United States of America Abstract Dendritic cells located at the body surfaces, e.g. skin, respiratory and gastrointestinal tract, play an essential role in the induction of adaptive immune responses to pathogens and inert antigens present at these surfaces. In the respiratory tract, multiple subsets of dendritic cells (RDC) have been identified in both the normal and inflamed lungs. While the importance of RDC in antigen transport from the inflamed or infected respiratory tract to the lymph nodes draining this site is well recognized, the contribution of individual RDC subsets to this process and the precise role of migrant RDC within the lymph nodes in antigen presentation to T cells is not clear. In this report, we demonstrate that two distinct subsets of migrant RDC - exhibiting the CD103+ hi ¨ + and CD11b phenotype, respectively - are the primary DC presenting antigen to naıve CD4 and CD8+ T lymphocytes in the draining nodes in response to respiratory influenza virus infection. Furthermore, the migrant CD103+ RDC subset preferentially drives efficient proliferation and differentiation of naive CD8+ T cells responding to infection into effector cells, and only the CD103+