原创力文档response to 2009 pandemic influenza a (h1n1) vaccine in hiv-infected patients and the influence of prior seasonal influenza vaccination应对2009年甲型流感(h1n1)疫苗感染艾滋病毒的病人和之前的季节性流感疫苗接种的影响.pdfVIP
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response to 2009 pandemic influenza a (h1n1) vaccine in hiv-infected patients and the influence of prior seasonal influenza vaccination应对2009年甲型流感(h1n1)疫苗感染艾滋病毒的病人和之前的季节性流感疫苗接种的影响
Response to 2009 Pandemic Influenza A (H1N1) Vaccine
in HIV-Infected Patients and the Influence of Prior
Seasonal Influenza Vaccination
1 2 3 1 1
Darius Soonawala *, Guus F. Rimmelzwaan , Luc B. S. Gelinck , Leo G. Visser , Frank P. Kroon
1 Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands, 2 Department of Virology, Erasmus Medical Center, Rotterdam, The
Netherlands, 3 Department of Internal Medicine, MC Haaglanden, the Hague, The Netherlands
Abstract
Background: The immunogenicity of 2009 pandemic influenza A(H1N1) (pH1N1) vaccines and the effect of previous
influenza vaccination is a matter of current interest and debate. We measured the immune response to pH1N1 vaccine in
HIV-infected patients and in healthy controls. In addition we tested whether recent vaccination with seasonal trivalent
inactivated vaccine (TIV) induced cross-reactive antibodies to pH1N1. ( Identifier:NC
Methods and Findings: In this single-center prospective cohort study MF59-adjuvanted pH1N1 vaccine (FocetriaH, Novartis)
was administered twice to 58 adult HIV-infected patients and 44 healthy controls in November 2009 (day 0 and day 21).
Antibody responses were measured at baseline, day 21 and day 56 with hemagglutination-inhibition (HI) assay. The
seroprotection rate (defined as HI titers $1:40) for HIV-infected patients was 88% after the first and 91% after the second
vaccination. These rates were comparable to those in healthy controls. Post-vaccination GMT, a sensitive marker of the
immune competence of a group, was lower in HIV-infected patients. We found a high seroprotection rate at baseline (31%).
Seroprotective titers at baseline were m
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