respiratory syncytial virus inhibits ciliagenesis in differentiated normal human bronchial epithelial cells effectiveness of n-acetylcysteine呼吸道合胞体病毒抑制ciliagenesis在人类支气管上皮细胞分化正常的防治效果.pdfVIP

Respiratory Syncytial Virus Inhibits Ciliagenesis in Differentiated Normal Human Bronchial Epithelial Cells: Effectiveness of N-Acetylcysteine 1,2 1 3,4 3 2,5 Manuel Mata *, Irene Sarrion , Miguel Armengot , Carmen Carda , Isidoro Martinez , Jose A. Melero2,6, Julio Cortijo1,2,3 ´ ´ 1 Research Foundation of the University General Hospital of Valencia, Valencia, Spain, 2 Centro de Investigacion Biomedica en Red (CIBER) de Enfermedades Respiratorias, ´ ´ Valencia, Spain, 3 University of Valencia, Valencia, Spain, 4 University General Hospital of Valencia, Valencia, Spain, 5 Unidad de Interaccion Virus-Celula, Centro Nacional ´ ´ ´ de Microbiologıa, Instituto de Salud Carlos II, Madrid, Spain, 6 Unidad de Biologıa Viral, Centro Nacional de Microbiologıa, Instituto de Salud Carlos II, Madrid, Spain Abstract Persistent respiratory syncytial virus (RSV) infections have been associated with the exacerbation of chronic inflammatory diseases, including chronic obstructive pulmonary disease (COPD). This virus infects the respiratory epithelium, leading to chronic inflammation, and induces the release of mucins and the loss of cilia activity, two factors that determine mucus clearance and the increase in sputum volume. These alterations involve reactive oxygen species-dependent me