relationship between periodontitis-related antibody and frequent exacerbations in chronic obstructive pulmonary diseaseperiodontitis-related抗体之间的关系和频繁的在慢性阻塞性肺疾病急性加重.pdfVIP

Relationship between Periodontitis-Related Antibody and Frequent Exacerbations in Chronic Obstructive Pulmonary Disease 1 1 1 1 1 Tamaki Takahashi , Shigeo Muro *, Naoya Tanabe , Kunihiko Terada , Hirofumi Kiyokawa , 1 1 2 3 4 5 Susumu Sato , Yuma Hoshino , Emiko Ogawa , Kazuko Uno , Koji Naruishi , Shogo Takashiba , Michiaki Mishima1 1 Department of Respiratory Medicine, Kyoto University, Kyoto, Japan, 2 Health Administration Center, Shiga University of Medical Science, Shiga, Japan, 3 Louis Pasteur Center for Medical Research, Kyoto, Japan, 4 Division of Endodontology, Iwate Medical University, Department of Conservative Dentistry and Oral Rehabilitation, Iwate, Japan, 5 Department of Pathophysiology–Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan Abstract Background: To identify patients with chronic obstructive pulmonary disease (COPD) who are susceptible to frequent exacerbations is important. Although periodontitis aggravated by poor oral hygiene might increase the risk of lower respiratory tract infection, the relationship between periodontitis and COPD exacerbations remains unknown. This prospective cohort study investigates the relationship between periodontitis-related antibody and exacerbation frequency over a one-year period. Methods: We assessed an IgG antibody titer against Porphyromonas gingivalis, which is a major pathogen of periodontitis, and then prospectively followed up 93 individuals over one year to detect exacerbations. Results: The numbers of exacerbations and the