risk of dementia in patients with insomnia and long-term use of hypnotics a population-based retrospective cohort study失眠患者的痴呆的风险和长期使用安眠药以人群为基础的回顾性队列研究.pdfVIP

Risk of Dementia in Patients with Insomnia and Long- term Use of Hypnotics: A Population-based Retrospective Cohort Study 1. 2,3,4. 5 1,7 3,6 Pin-Liang Chen , Wei-Ju Lee , Wei-Zen Sun , Yen-Jen Oyang , Jong-Ling Fuh * 1 Department of Computer Science and Information Engineering, National Taiwan University, Taipei, Taiwan, 2 Department of Neurology, Taichung Veterans General Hospital, Taichung, Taiwan, 3 Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, 4 Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, 5 Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan, 6 Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, 7 Graduate Institutes of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan Abstract Background: Hypnotics have been reported to be associated with dementia. However, the relationship between insomnia, hypnotics and dementia is still controversial. We sought to examine the risk of dementia in patients with long-term insomnia and the contribution of hypnotics. Methods: Data was collected from Taiwan’s Longitudinal Health Insurance Database. The study cohort comprised all patients aged 50 years or older with a first diagnosis of insomnia from 2002 to 2007. The comparison cohort consisted of randomly selected patients matched by age and gender. Each patient was individually tracked for 3 years from their insomnia index date to identify whether the patient had a first diagnosis of dementia. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Res