原创力文档risk of cardiovascular disease in a traditional african population with a high infectious load a population-based study心血管疾病的风险在传统的非洲人口高传染性负载以人群为基础的研究.pdfVIP
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risk of cardiovascular disease in a traditional african population with a high infectious load a population-based study心血管疾病的风险在传统的非洲人口高传染性负载以人群为基础的研究
Risk of Cardiovascular Disease in a Traditional African
Population with a High Infectious Load: A Population-
Based Study
1 2,5 3 4,5,1
Jacob J. E. Koopman *, David van Bodegom , J. Wouter Jukema , Rudi G. J. Westendorp
1 Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands, 2 Department of Gerontology and Geriatrics, Leiden University
Medical Center, Leiden, The Netherlands, 3 Department of Cardiology, Leiden University Medical ZCenter, Leiden, The Netherlands, 4 Department of Gerontology
and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands, 5 Leyden Academy on Vitality and Ageing, Leiden, T he Net herlands
Abstract
Background: To test the inflammatory origin of cardiovascular disease, as opposed to its origin in western lifestyle.
Population-based assessment of the prevalences of cardiovascular risk factors and cardiovascular disease in an
inflammation-prone African population, including electrocardiography and ankle-arm index measurement. Comparison
with known prevalences in American and European societies.
Methodology/Principal Findings: Traditional population in rural Ghana, characterised by adverse environmental conditions
and a high infectious load. Population-based sample of 924 individuals aged 50 years and older. Median values for
cardiovascular risk factors, including waist circumference, BMI, blood pressure, and markers of glucose and lipid metabolism
and inflammation. Prevalence of myocardial infarction detected by electrocardiography and prevalence of peripheral arterial
disease detected by ankle-arm index. When compared to western socie
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