原创力文档risk of subsequent coronary heart disease in patients hospitalized for immune-mediated diseases a nationwide follow-up study from sweden随后的冠心病患者住院的风险免疫介导性疾病来自瑞典的一个全国性的后续研究.pdfVIP
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risk of subsequent coronary heart disease in patients hospitalized for immune-mediated diseases a nationwide follow-up study from sweden随后的冠心病患者住院的风险免疫介导性疾病来自瑞典的一个全国性的后续研究
Risk of Subsequent Coronary Heart Disease in Patients
Hospitalized for Immune-Mediated Diseases: A
Nationwide Follow-Up Study from Sweden
¨ 1 1 1,2 1
Bengt Zoller *, Xinjun Li , Jan Sundquist , Kristina Sundquist
˚ ˚ ¨
1 Center for Primary Health Care Research, Lund University/Region Skane, Clinical Research Centre, Skane University Hospital, Malmo, Sweden, 2 Stanford Prevention
Research Center, Stanford University School of Medicine, Stanford, California, United States of America
Abstract
Background: Certain immune-mediated diseases (IMDs), such as rheumatoid arthritis and systemic lupus erythematosus,
have been linked to cardiovascular disorders. We examined whether there is an association between 32 different IMDs and
risk of subsequent hospitalization for coronary heart disease (CHD) related to coronary atherosclerosis in a nationwide
follow up study in Sweden.
Methods and Findings: All individuals in Sweden hospitalized with a main diagnosis of an IMD (n = 336,479) without
previous or coexisting CHD, between January 1, 1964 and December 31 2008, were followed for first hospitalization for
CHD. The reference population was the total population of Sweden. Standardized incidence ratios (SIRs) for CHD were
calculated. Overall risk of CHD during the first year after hospitalization for an IMD was 2.92 (95% CI 2.84–2.99). Twenty-
seven of the 32 IMDs studied were associated with an increased risk of CHD during the first year after hospitalization. The
overall risk of CHD decreased over time, from 1.75 after 1–5 years (95% CI 1.73–1.78), to 1.43 after 5–10 years (95% CI 1.41–
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