原创力文档risk of ovarian cancer and inherited variants in relapse-associated genes卵巢癌的风险和relapse-associated基因的遗传变异.pdfVIP
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risk of ovarian cancer and inherited variants in relapse-associated genes卵巢癌的风险和relapse-associated基因的遗传变异
Risk of Ovarian Cancer and Inherited Variants in
Relapse-Associated Genes
1 1 1 1
Abraham Peedicayil , Robert A. Vierkant , Lynn C. Hartmann , Brooke L. Fridley , Zachary S.
1 1 1 2 2 3
Fredericksen , Kristin L. White , Elaine A. Elliott , Catherine M. Phelan , Ya-Yu Tsai , Andrew Berchuck ,
3 1 1 1 1
Edwin S. Iversen, Jr , Fergus J. Couch , Prema Peethamabaran , Melissa C. Larson , Kimberly R. Kalli ,
1 1 1 1 1
Matthew L. Kosel , Vijayalakshmi Shridhar , David N. Rider , Mark Liebow , Julie M. Cunningham ,
3 2 1
Joellen M. Schildkraut , Thomas A. Sellers , Ellen L. Goode *
1 Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America, 2 H. Lee Moffitt Cancer Research Institute, Tampa, Florida, United States of America,
3 Duke University, Durham, North Carolina, United States of America
Abstract
Background: We previously identified a panel of genes associated with outcome of ovarian cancer. The purpose of the
current study was to assess whether variants in these genes correlated with ovarian cancer risk.
Methods and Findings: Women with and without invasive ovarian cancer (749 cases, 1,041 controls) were genotyped at 136
single nucleotide polymorphisms (SNPs) within 13 candidate genes. Risk was estimated for each SNP and for overal
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