原创力文档risk factors of household transmission of pandemic (h1n1) 2009 among patients treated with antivirals a prospective study at a primary clinic in japan风险因素的家庭传播2009年h1n1流感大流行在抗病毒药物患者的前瞻性研究主要在日本诊所.pdfVIP
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risk factors of household transmission of pandemic (h1n1) 2009 among patients treated with antivirals a prospective study at a primary clinic in japan风险因素的家庭传播2009年h1n1流感大流行在抗病毒药物患者的前瞻性研究主要在日本诊所
Risk Factors of Household Transmission of Pandemic
(H1N1) 2009 among Patients Treated with Antivirals: A
Prospective Study at a Primary Clinic in Japan
1 2 3
Nobuo Hirotsu , Koji Wada *, Hitoshi Oshitani
1 Hirotsu Clinic, Kawasaki, Japan, 2 Department of Public Health, Kitasato University School of Medicine, Sagamihara, Japan, 3 Department of Virology, Tohoku University
Graduate School of Medicine, Sendai, Japan
Abstract
Background: Household transmission of influenza can affect the daily lives of patients and their families and be a trigger for
community transmission, thus it is necessary to take precautions to prevent household transmission. We aimed to
determine the risks of household transmission of pandemic (H1N1) 2009 influenza virus from an index patient who visited a
primary clinic and was treated with antiviral drugs.
Methods: We followed up all the patients who were diagnosed with influenza A by rapid diagnostic test with a
questionnaire or interview from July 2009 to April 2010. Secondary cases were defined as patients visiting the clinic or other
clinics and being positive for influenza A by rapid diagnostic test within 7 days of onset of an index patient. Logistic
regression analysis was used to explore the association between household transmission and the studied variables.
Results: We recruited 591 index patients and 1629 household contacts. The crude secondary attack rate was 7.3% [95%
confidence interval (CI): 6.1–8.7]. Age of index patients (0–6 years old: odds ratio 2.56; 95% CI: 1.31–4.01; 7–12 years old:
2.44, 1.31–3.72; 30–39 years old 3.88; 2.09–5.21; 40 years old or more 2.76; 1.17–4.53) and number of household members
with five or more (3.09, 2.11–4.07), medication started $48 hours fro
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