risk factors for breast cancer and expression of insulin-like growth factor-2 (igf-2) in women with breast cancer in wuhan city, china乳腺癌的危险因素和表达胰岛素样生长因子2(igf-2)患有乳腺癌的妇女在武汉城市,中国.pdfVIP

Risk Factors for Breast Cancer and Expression of Insulin- Like Growth Factor-2 (IGF-2) in Women with Breast Cancer in Wuhan City, China 1 2 3 1 1 Jun Qiu , Rong Yang , Yanhua Rao , Yukai Du *, Fatch W. Kalembo 1 Department of Maternal and Child Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2 Centre of Wuhan City Maternal and Child Health Care, Qiaokou, China, 3 Center of Jiangxia District Maternal and Child Health Care, Jiangxi, China Abstract Purpose: The purpose of this study was to explore the risk factors for breast cancer and establish the expression rate of IGF- 2 in female patients. Methods: A case control study with 500 people in case group and 500 people in control group. A self-administered questionnaire was used to investigate risk factors for breast cancer. All cases were interviewed during a household survey. Immune-histochemical method was used to inspect the expression of IGF-2 in different tissues (benign breast lesions, breast cancer and tumor-adjacent tissue). Results: Multivariate adjusted odds ratios and 95% confidence intervals were calculated using unconditional logistic regression. High body mass index (OR = 1.012,95%CI = 1.008–1.016), working attributes (OR = 1.004, 95%CI = 1.002 = 1.006), long menstrual period (OR = 1.007, 95%CI = 1.005–1.009), high parity OR = 1.003, 95%CI = 1.001–1.005) , frequent artificial abortion (OR = 1.004, 95%CI = 1.001–1.005), family history of cancer (OR = 1.003, 95%CI = 1.000–1.005), period of night shift (OR = 1.003, 95%CI = 1.001–1.006), live in high risk environment (OR = 1.005, 95%CI = 1.002–1.008), and family problems (OR = 1.010, 95%CI = 1.005–1.014) were associated with increased risk for breast cancer. In