risk factors and immunity in a nationally representative population following the 2009 influenza a(h1n1) pandemic风险因素和免疫后全国代表性的人口2009年甲型(h1n1)流感大流行.pdfVIP

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risk factors and immunity in a nationally representative population following the 2009 influenza a(h1n1) pandemic风险因素和免疫后全国代表性的人口2009年甲型(h1n1)流感大流行.pdf

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risk factors and immunity in a nationally representative population following the 2009 influenza a(h1n1) pandemic风险因素和免疫后全国代表性的人口2009年甲型(h1n1)流感大流行

Risk Factors and Immunity in a Nationally Representative Population following the 2009 Influenza A(H1N1) Pandemic 1 1 1 1 2 Don Bandaranayake , Q. Sue Huang *, Ange Bissielo , Tim Wood , Graham Mackereth , Michael G. 3 4 5 6 1 Baker , Richard Beasley , Stewart Reid , Sally Roberts , Virginia Hope , on behalf of the 2009 H1N1 serosurvey investigation team 1 Institute of Environmental Science and Research, National Centre for Biosecurity and Infectious Disease, Upper Hutt, New Zealand, 2 Ministry of Health, Wellington, New Zealand, 3 Wellington School of Medicine, University of Otago, Wellington, New Zealand, 4 Medical Research Institute of New Zealand, Wellington Hospital, Wellington, New Zealand, 5 Ropata Medical Centre, Lower Hutt, New Zealand, 6 Department of Microbiology, Auckland District Health Board, Auckland, New Zealand Abstract Background: Understanding immunity, incidence and risk factors of the 2009 influenza A(H1N1) pandemic (2009 H1N1) through a national seroprevalence study is necessary for informing public health interventions and disease modelling. Methods and Findings: We collected 1687 serum samples and individual risk factor data between November-2009 to March-2010, three months after the end of the 2009 H1N1 wave in New Zealand. Participants were randomly sampled from selected general practices countrywide and hospitals in the Auckland region. Baseline immunity was measured from 521 sera collected during 2004 to April-2009. Haemagglutination inhibition (HI) antibody titres of $1:40 against 2009 H1N1 were considered seroprotective as well as seropositive. The overall community seroprevalence was 26.7% (CI:22.6–29.4).