resistance to first-line anti-tb drugs is associated with reduced nitric oxide susceptibility in mycobacterium tuberculosis对一线抗结核药物与降低一氧化氮在结核分枝杆菌敏感性.pdfVIP

Resistance to First-Line Anti-TB Drugs Is Associated with Reduced Nitric Oxide Susceptibility in Mycobacterium tuberculosis 1 2,3 1,3,4 3 5 Jonna Idh *, Mekidim Mekonnen , Ebba Abate , Wassihun Wedajo , Jim Werngren , ¨ 6 1 7 1 3 1 Kristian Angeby , Maria Lerm , Daniel Elias , Tommy Sundqvist , Abraham Aseffa , Olle Stendahl , ¨ 8 Thomas Schon ¨ ¨ 1 Division of Microbiology and Molecular Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden, 2 Department of Microbiology, Immunology and Parasitology, Addis Ababa University, Debre Zeit, Ethiopia, 3 Armauer Hansen Research Institute, Addis Ababa, Ethiopia, 4 Department of Microbiology and Parasitology, Gondar University Hospital, Gondar, Ethiopia, 5 Unit of Highly Pathogenic Microorganisms, Department of Preparedness, Swedish Institute for Communicable Disease Control, Solna, Sweden, 6 Clinical Microbiology, MTC, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, 7 Department of Cancer and Inflammation, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark, 8 Department of Infectious Diseases and Department of Clinical Microbiology, Kalmar County Hospital, Kalmar, Sweden Abstract Background and Objective: The relative contribution of nitric oxide (NO) to the killing of Mycobacterium tuberculosis in human tuberculosis (TB) is controversial, although this has been firmly established in rodents. Studies have demonstrated that clinical strains of M. tuberculosis differ in sus