原创力文档relation between mild to moderate chronic kidney disease and coronary artery disease determined with coronary ct angiography轻度至中度慢性肾脏疾病之间的关系与冠状动脉ct血管造影和冠状动脉疾病.pdfVIP
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relation between mild to moderate chronic kidney disease and coronary artery disease determined with coronary ct angiography轻度至中度慢性肾脏疾病之间的关系与冠状动脉ct血管造影和冠状动脉疾病
Relation between Mild to Moderate Chronic Kidney
Disease and Coronary Artery Disease Determined with
Coronary CT Angiography
1 2 1 1 1
Ivo A. Joosen *, Frank Schiphof , Mathijs O. Versteylen , Eduard M. Laufer , Mark H. Winkens ,
3 4 5 2 2,6
Patricia J. Nelemans , Jeroen P. Kooman , Leonard Hofstra , Joachim E. Wildberger , Tim Leiner
1 Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands, 2 Department of Radiology,
Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands, 3 Department of Epidemiology, Maastricht University
Medical Center, Maastricht, The Netherlands, 4 Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands, 5 Cardiology Center
Netherlands, Utrecht, The Netherlands, 6 Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
Abstract
Background: Both end-stage and milder stages of chronic kidney disease (CKD) are associated with an increased risk of
adverse cardiovascular events. Several studies found an association between decreasing renal function and increasing
coronary artery calcification, but it remains unclear if this association is independent from traditional cardiovascular risk
factors. Therefore, the aim of this study was to investigate whether mild to moderate CKD is independently associated with
coronary plaque burden beyond traditional cardiovascular risk factors.
Methods: A total of 2,038 patients with symptoms of chest discomfort suspected for cor
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