relationship between expression of the family of m proteins and lipoteichoic acid to hydrophobicity and biofilm formation in streptococcus pyogenes关系表达式m蛋白家族和lipoteichoic酸酿脓链球菌的疏水性和生物膜的形成.pdfVIP

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relationship between expression of the family of m proteins and lipoteichoic acid to hydrophobicity and biofilm formation in streptococcus pyogenes关系表达式m蛋白家族和lipoteichoic酸酿脓链球菌的疏水性和生物膜的形成.pdf

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relationship between expression of the family of m proteins and lipoteichoic acid to hydrophobicity and biofilm formation in streptococcus pyogenes关系表达式m蛋白家族和lipoteichoic酸酿脓链球菌的疏水性和生物膜的形成

Relationship between Expression of the Family of M Proteins and Lipoteichoic Acid to Hydrophobicity and Biofilm Formation in Streptococcus pyogenes 1,4 1,5 1 6 6 Harry S. Courtney *, Itzhak Ofek , Thomas Penfound , Victor Nizet , Morgan A. Pence , Bernd 7 7 2,4 1,3,4 Kreikemeyer , Andreas Podbielbski , David L. Hasty , James B. Dale 1 Department of Medicine, University of Tennessee, Memphis, Tennessee, United States of America, 2 Department of Anatomy and Neurobiology, University of Tennessee, Memphis, Tennessee, United States of America, 3 Department of Molecular Sciences, University of Tennessee, Memphis, Tennessee, United States of America, 4 Department of Veterans Affairs Medical Center, University of Tennessee, Memphis, Tennessee, United States of America, 5 Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 6 Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America, 7 Department of Medical Microbiology and Hospital Hygiene, Hospital of Rostock University, Rostock, Germany Abstract Background: Hydrophobicity is an important attribute of bacteria that contributes to adhesion and biofilm formation. Hydrophobicity of Streptococcus pyogenes is primarily due to lipoteichoic acid (LTA) on the streptococcal surface but the mechanism(s) whereby LTA is retained on the surface is poorly understood. In this study, we sought to determine whether members of the M protein family consisting of Emm (M protein), Mrp (M-related protein), Enn (an M-like protein), and the streptococcal protective antige