refractoriness of eryptotic red blood cells to plasmodium falciparum infection a putative host defense mechanism limiting parasitaemia耐火性eryptotic血红细胞的恶性疟原虫感染一个假定的限制parasitaemia宿主防御机制.pdfVIP

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refractoriness of eryptotic red blood cells to plasmodium falciparum infection a putative host defense mechanism limiting parasitaemia耐火性eryptotic血红细胞的恶性疟原虫感染一个假定的限制parasitaemia宿主防御机制.pdf

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refractoriness of eryptotic red blood cells to plasmodium falciparum infection a putative host defense mechanism limiting parasitaemia耐火性eryptotic血红细胞的恶性疟原虫感染一个假定的限制parasitaemia宿主防御机制

Refractoriness of Eryptotic Red Blood Cells to Plasmodium falciparum Infection: A Putative Host Defense Mechanism Limiting Parasitaemia ´ ´ Paulo Renato Rivas Totino, Claudio Tadeu Daniel-Ribeiro, Maria de Fatima Ferreira-da-Cruz* Laboratory of Malaria Research, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brasil Abstract Recently, we have described that apoptosis-like process of red blood cells (RBC) – eryptosis – in malaria is not restricted to parasitized cells, occurring also in non-parasitized RBC (nRBC). Besides to pathogenic proprieties, apoptosis also participates in the innate defense trough restriction of intracellular pathogens propagation. In the present study, we investigated the capacity of P. falciparum parasites to infect eryptotic RBC. Schizont parasitized RBC concentrated by magnetic separation were cultured with eryptotic RBC obtained by ionomycin treatment and, then, parasite growth was evaluated in Giemsa- stained thin blood smears. While parasites infected and developed normally in control non-eryptotic RBC, cultures performed with eryptotic RBC had a marked decrease in parasitaemia. It was noteworthy a great number of free merozoites in eryptotic RBC cultures, indicating that these cells were not susceptible to invasion. We suggest that although eryptosis could be involved in malaria pathogenesis, it could also acting protectively by controlling parasite propagation. Citation: Totino PRR, Daniel-Ribeiro CT, Ferreira-da-Cruz MdF (2011) Refractoriness of Eryptotic Red Blood Cells to Plasmodium falciparum Infection: A Putative Host Defense Mechanism Limiting Parasitaemia. PLoS ONE 6(10): e26575. doi:10.1371/journal.pone.0026575 Editor: Fabio T. M. Costa, State University of Campinas, Brazil Received June 27, 2011;