原创力文档relation between the global burden of disease and randomized clinical trials conducted in latin america published in the five leading medical journals之间的关系进行的全球疾病负担和随机临床试验在拉丁美洲在五个著名医学期刊上发表.pdfVIP
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relation between the global burden of disease and randomized clinical trials conducted in latin america published in the five leading medical journals之间的关系进行的全球疾病负担和随机临床试验在拉丁美洲在五个著名医学期刊上发表
Relation between the Global Burden of Disease and
Randomized Clinical Trials Conducted in Latin America
Published in the Five Leading Medical Journals
1 1,2 3 1
Pablo Perel , J. Jaime Miranda *, Zulma Ortiz , Juan Pablo Casas
1 Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom, 2 School of Public Health and
Administration, Universidad Peruana Cayetano Heredia, Lima, Peru, 3 Epidemiological Research Institute, National Academy of Medicine, Buenos Aires, Argentina
Abstract
Background: Since 1990 non communicable diseases and injuries account for the majority of death and disability-adjusted
life years in Latin America. We analyzed the relationship between the global burden of disease and Randomized Clinical
Trials (RCTs) conducted in Latin America that were published in the five leading medical journals.
Methodology/Principal Findings: We included all RCTs in humans, exclusively conducted in Latin American countries, and
published in any of the following journals: Annals of Internal Medicine, British Medical Journal, Journal of the American
Medical Association, Lancet, and New England Journal of Medicine. We described the trials and reported the number of RCTs
according to the main categories of the global burden of disease. Sixty-six RCTs were identified. Communicable diseases
accounted for 38 (57%) reports. Maternal, perinatal, and nutritional conditions accounted for 19 (29%) trials. Non-
communicable diseases represent 48% of the global burden of disease but only 14% of reported trials. No trial addressed
injuries despite its 18% contribution to the burden of disease in 2000.
Conclusions/Significance: A poor correlation betwe
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