原创力文档relating the chondrocyte gene network to growth plate morphology from genes to phenotype相关基因的基因网络生长板软骨细胞形态学表型.pdfVIP
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relating the chondrocyte gene network to growth plate morphology from genes to phenotype相关基因的基因网络生长板软骨细胞形态学表型
Relating the Chondrocyte Gene Network to Growth Plate
Morphology: From Genes to Phenotype
Johan Kerkhofs1,2,3, Scott J. Roberts3,4, Frank P. Luyten3,4, Hans Van Oosterwyck2,3, Liesbet Geris1,3*
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1 Biomechanics Research Unit, University of Liege, Liege, Belgium, 2 Biomechanics section, K.U. Leuven, Leuven, Belgium, 3 Prometheus, The Leuven RD division of
skeletal tissue engineering, K.U. Leuven, Leuven, Belgium, 4 Rheumatology Department, K.U. Leuven, Leuven, Belgium
Abstract
During endochondral ossification, chondrocyte growth and differentiation is controlled by many local signalling pathways.
Due to crosstalks and feedback mechanisms, these interwoven pathways display a network like structure. In this study, a
large-scale literature based logical model of the growth plate network was developed. The network is able to capture the
different states (resting, proliferating and hypertrophic) that chondrocytes go through as they progress within the growth
plate. In a first corroboration step, the effect of mutations in various signalling pathways of the growth plate network was
investigated.
Citation: Kerkhofs J, Roberts SJ, Luyten FP, Van Oosterwyck H, Geris L (2012) Relating the Chondrocyte Gene Network to Growth Plate Morphology: From Genes
to Phenotype. PLoS ONE 7(4): e34729. doi:10.1371/journal.pone.0034729
Editor: Zhongjun Zhou, The University of Hong Kong, Hong Kong
Received October 5, 2011; Accepted March 8, 2012; Published April 30, 2012
Copyright: 2012 Kerkhofs et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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