原创力文档risk factors associated with positive quantiferon-tb gold in-tube and tuberculin skin tests results in zambia and south africa风险因素与积极quantiferon-tb黄金管和结核菌素皮肤试验结果在赞比亚和南非.pdfVIP
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risk factors associated with positive quantiferon-tb gold in-tube and tuberculin skin tests results in zambia and south africa风险因素与积极quantiferon-tb黄金管和结核菌素皮肤试验结果在赞比亚和南非
Risk Factors Associated with Positive QuantiFERON-TB
Gold In-Tube and Tuberculin Skin Tests Results in
Zambia and South Africa
1 2 2 1,2 4
Kwame Shanaube *, James Hargreaves , Katherine Fielding , Ab Schaap , Katherine-Anne Lawrence ,
3 5 4 4 1,3
Bernadette Hensen , Charalambos Sismanidis , Angela Menezes , Nulda Beyers , Helen Ayles , Peter
Godfrey-Faussett3
1 ZAMBART Project, University of Zambia, Lusaka, Zambia, 2 Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London,
United Kingdom, 3 Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, United Kingdom, 4 Desmond Tutu TB Centre, Stellenbosch
University, Stellenbosch, South Africa, 5 Stop TB Department, Monitoring and Evaluation Unit, World Health Organization, Geneva, Switzerland
Abstract
Introduction: The utility of T-cell based interferon-gamma release assays for the diagnosis of latent tuberculosis infection
remains unclear in settings with a high burden of tuberculosis.
Objectives: To determine risk factors associated with positive QuantiFERON-TB Gold In-Tube (QFT-GIT) and tuberculin skin
test (TST) results and the level of agreement between the tests; to explore the hypotheses that positivity in QFT-GIT is more
related to recent infection and less affected by HIV than the TST.
Methods: Adult household contacts of tuberculosis patients were invited to participate in a cross-sectional study across 24
communities in Zambia and South Africa. HIV, QFT-GIT and TST tests were done. A que
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