seasonal differences of gene expression profiles in song sparrow (melospiza melodia) hypothalamus in relation to territorial aggression季节性的差异基因表达谱在北美歌雀(melospiza笛管音栓)下丘脑与领土的侵略.pdfVIP

Seasonal Differences of Gene Expression Profiles in Song Sparrow (Melospiza melodia) Hypothalamus in Relation to Territorial Aggression 1,2 3,4 6 7¤a 7¤b 6 Motoko Mukai *, Kirstin Replogle , Jenny Drnevich , Gang Wang , Douglas Wacker , Mark Band , David F. Clayton3,4,5, John C. Wingfield1,7 1 Department of Neurobiology, Physiology, and Behavior, University of California Davis, Davis, California, United States of America, 2 Department of Veterinary Biosciences, University of Illinois, Champaign, Illinois, United States of America, 3 Department of Cell and Developmental Biology, University of Illinois, Champaign, Illinois, United States of America, 4 Institute for Genomic Biology, University of Illinois, Champaign, Illinois, United States of America, 5 Neuroscience Program, University of Illinois, Champaign, Illinois, United States of America, 6 W.M. Keck Center for Comparative and Functional Genomics, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, 7 Department of Biology, University of Washington, Seattle, Washington, United States of America Abstract Background: Male song sparrows (Melospiza melodia) are territorial year-round; however, neuroendocrine responses to simulated territorial intrusion (STI) differ between breeding (spring) and non-breeding seasons (autumn). In spring, exposure to STI leads to increases in luteinizing hormone and testosterone, but not in autumn. These observations suggest that there are fundamental differences in the mechanisms driving neuroendocrine responses to STI between seasons. Microarrays, spotted with EST cDNA clones of zebra finch, were used to explore gene expression profiles in the hypo