原创力文档season of conception in rural gambia affects dna methylation at putative human metastable epialleles观念在农村冈比亚的季节影响dna甲基化在人类亚稳epialleles假定的.pdfVIP
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season of conception in rural gambia affects dna methylation at putative human metastable epialleles观念在农村冈比亚的季节影响dna甲基化在人类亚稳epialleles假定的
Season of Conception in Rural Gambia Affects DNA
Methylation at Putative Human Metastable Epialleles
1,2 1 1 3 2
Robert A. Waterland *, Richard Kellermayer , Eleonora Laritsky , Pura Rayco-Solon , R. Alan Harris ,
4 1 1 5 1 1
Michael Travisano , Wenjuan Zhang , Maria S. Torskaya , Jiexin Zhang , Lanlan Shen , Mark J. Manary ,
Andrew M. Prentice3
1 Department of Pediatrics, Baylor College of Medicine, USDA/ARS Children’s Nutrition Research Center, Houston, Texas, United States of America, 2 Department of
Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, 3 MRC International Nutrition Group, London School of Hygiene
and Tropical Medicine, London, United Kingdom, 4 Department of Ecology, Evolution, and Behavior, University of Minnesota, St. Paul, Minnesota, United States of
America, 5 Department of Biostatistics and Applied Biomathematics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
Abstract
Throughout most of the mammalian genome, genetically regulated developmental programming establishes diverse yet
predictable epigenetic states across differentiated cells and tissues. At metastable epialleles (MEs), conversely, epigenotype
is established stochastically in the early embryo then maintained in differentiated lineages, resulting in dramatic and
systemic interindividual variation in epigenetic regulation. In the mouse, maternal nutrition affects this process, with
permanent phenotypic consequences for the offspring. MEs have not previous
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