原创力文档role of the endogenous antioxidant system in the protection of schistosoma mansoni primary sporocysts against exogenous oxidative stress保护作用的内源性抗氧化系统对外源氧化应激的曼氏裂体吸虫主要孢囊.pdfVIP
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role of the endogenous antioxidant system in the protection of schistosoma mansoni primary sporocysts against exogenous oxidative stress保护作用的内源性抗氧化系统对外源氧化应激的曼氏裂体吸虫主要孢囊
Role of the Endogenous Antioxidant System in the
Protection of Schistosoma mansoni Primary Sporocysts
against Exogenous Oxidative Stress
˜ 1. 2. ´ 1 2
Marina de Moraes Mourao , Nathalie Dinguirard , Gloria R. Franco , Timothy P. Yoshino *
´ ˆ ´
1 Departamento de Bioquımica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil, 2 Department of
Pathobiological Sciences, University of Wisconsin, Madison, Wisconsin, United States of America
Abstract
Antioxidants produced by the parasite Schistosoma mansoni are believed to be involved in the maintenance of cellular
redox balance, thus contributing to larval survival in their intermediate snail host, Biomphalaria glabrata. Here, we focused
on specific antioxidant enzymes, including glutathione-S-transferases 26 and 28 (GST26 and 28), glutathione peroxidase
(GPx), peroxiredoxin 1 and 2 (Prx1 and 2) and Cu/Zn superoxide dismutase (SOD), known to be involved in cellular redox
reactions, in an attempt to evaluate their endogenous antioxidant function in the early-developing primary sporocyst stage
of S. mansoni. Previously we demonstrated a specific and consistent RNA interference (RNAi)-mediated knockdown of GST26
and 28, Prx1 and 2, and GPx transcripts, and an unexpected elevation of SOD transcripts in sporocysts treated with gene-
specific double-stranded (ds)RNA. In the present followup study, in vitro transforming sporocysts were exposed to dsRNAs
for GST26 and 28, combined Prx1/2, GPx, SOD or green-fluorescent protein (GFP, control) for 7 days in culture, followed by
assessment of the effects
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