原创力文档risk assessment of transmission of sporadic creutzfeldt-jakob disease in endodontic practice in absence of adequate prion inactivation零星的克雅氏病的传播疾病的风险评估在牙髓学的实践缺乏足够的朊病毒失活.pdfVIP
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risk assessment of transmission of sporadic creutzfeldt-jakob disease in endodontic practice in absence of adequate prion inactivation零星的克雅氏病的传播疾病的风险评估在牙髓学的实践缺乏足够的朊病毒失活
Risk Assessment of Transmission of Sporadic Creutzfeldt-
Jakob Disease in Endodontic Practice in Absence of
Adequate Prion Inactivation
` 1,2 1,2,3 4,5,6 1,2,3
Nadege Bourvis , Pierre-Yves Boelle , Jean-Yves Cesbron , Alain-Jacques Valleron *
´ ´ ´ ` ´
1 Universite Pierre et Marie Curie-Paris6, Unite de Recherche Epidemiologie-Systemes d’information-Modelisation, UMR S 707, Paris, France, 2 INSERM,
ˆ ´ ´ ˆ
U707, Paris, France, 3 Assistance Publique-Hopitaux de Paris (AP-HP), Unite de Sante Publique, Hopital St Antoine, Paris, France, 4 Laboratoire
´ ´
Adaptation et de Pathogenie des Micro-organismes, Universite Joseph Fourier, UMR 5163, Grenoble, France, 5 Centre National de la Recherche
Scientifique (CNRS), UMR 5163, Grenoble, France, 6 Centre hospitalier universitaire (CHU) de Grenoble, Laboratoire d’Immunologie, Grenoble, France
Background. Experimental results evidenced the infectious potential of the dental pulp of animals infected with transmissible
spongiform encephalopathies (TSE). This route of iatrogenic transmission of sporadic Creutzfeldt-Jakob disease (sCJD) may
exist in humans via reused endodontic instruments if inadequate prion decontamination procedures are used. Methodology/
Principal Findings. To assess this risk, 10 critical parameters in the transmission process were identified, starting with
contamination of an endodontic file during treatment of an infectious sCJD patient and ending with possible infection of a
subsequent susceptible patient. It was assumed that a dose-
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