residential proximity to a major roadway is associated with features of asthma control in children住宅靠近主要道路与儿童哮喘控制的特性有关.pdfVIP

Residential Proximity to a Major Roadway Is Associated with Features of Asthma Control in Children 1 2 1 1,3 1 Meredith S. Brown , Stefanie Ebelt Sarnat , Karen A. DeMuth , Lou Ann S. Brown , Denise R. Whitlock , 1 2 1,3 Shanae W. Brown , Paige E. Tolbert , Anne M. Fitzpatrick * 1 Department of Pediatrics, Emory University School of Medicine, Emory University, Atlanta, Georgia, United States of America, 2 Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America, 3 Children’s Healthcare of Atlanta Center for Developmental Lung Biology, Atlanta, Georgia, United States of America Abstract Background: While several studies suggest that traffic-related air pollutants are detrimental for respiratory health, few studies have examined relationships between residential proximity to a major roadway and asthma control in children. Furthermore, a major limitation of existing research is reliance on self-reported outcomes. We therefore determined the spatial relationship between the distance from a major roadway and clinical, physiologic and inflammatory features of asthma in a highly characterized sample of asthmatic children 6–17 years of age across a wide range of severities. We hypothesized that a closer residential proximity to a major roadway would be associated with increased respiratory symptoms, altered pulmonary function and a greater magnitude of airway and systemic inflammation.