risk compensation is not associated with male circumcision in kisumu, kenya a multi-faceted？assessment？of men enrolled in a randomized controlled trial风险补偿不与基苏姆的男性包皮环切相关,肯尼亚一个多方面的评估男人进入了一个随机对照试验.pdfVIP

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risk compensation is not associated with male circumcision in kisumu, kenya a multi-faceted？assessment？of men enrolled in a randomized controlled trial风险补偿不与基苏姆的男性包皮环切相关,肯尼亚一个多方面的评估男人进入了一个随机对照试验.pdf

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risk compensation is not associated with male circumcision in kisumu, kenya a multi-faceted？assessment？of men enrolled in a randomized controlled trial风险补偿不与基苏姆的男性包皮环切相关,肯尼亚一个多方面的评估男人进入了一个随机对照试验

Risk Compensation Is Not Associated with Male Circumcision in Kisumu, Kenya: A Multi- Faceted Assessment of Men Enrolled in a Randomized Controlled Trial 1 1 1 2 3 Christine L. Mattson *, Richard T. Campbell , Robert C. Bailey , Kawango Agot , J. O. Ndinya-Achola , Stephen Moses4 1 School of Public Health, University of Illinois at Chicago, Chicago, Illinois, United States of America, 2 UNIM Project, Kisumu, Kenya, 3 Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya, 4 Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada Abstract Background: Three randomized controlled trials (RCTs) have confirmed that male circumcision (MC) significantly reduces acquisition of HIV-1 infection among men. The objective of this study was to perform a comprehensive, prospective evaluation of risk compensation, comparing circumcised versus uncircumcised controls in a sample of RCT participants. Methods and Findings: Between March 2004 and September 2005, we systematically recruited men enrolled in a RCT of MC in Kenya. Detailed sexual histories were taken using a modified Timeline Followback approach at baseline, 6, and 12 months. Participants provided permission to obtain circumcision status and laboratory results from the RCT. We evaluated circumcised and uncircumcised men’s sexual behavior using an 18-item risk propensity score and acquisition of incident infections of gonorrhea, chlamydia, and trichomoniasis. Of 1780 eligible RCT participants, 1319 enrolled (response rate = 74%). At the baseline RCT visit, men who enrolled in the sub-study reported the same sexual behaviors as men who did not. We found a significant reduction in sexual risk be