原创力文档seasonal childhood anaemia in west africa is associated with the haptoglobin 2-2 genotype季节性儿童贫血在西非与结合珠蛋白2基因型.pdfVIP
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seasonal childhood anaemia in west africa is associated with the haptoglobin 2-2 genotype季节性儿童贫血在西非与结合珠蛋白2基因型
PLoS MEDICINE
Seasonal Childhood Anaemia in West Africa Is
Associated with the Haptoglobin 2-2 Genotype
1,2,3* 3 1 3 2 4
Sarah H. Atkinson , Kirk Rockett , Giorgio Sirugo , Philip A. Bejon , Anthony Fulford , Maria A. O’Connell ,
Robin Bailey1 3 1,2
, Dominic P. Kwiatkowski , Andrew M. Prentice
1 Medical Research Council Laboratories, Banjul, The Gambia, 2 Medical Research Council International Nutrition Group, Nutrition and Public Health Intervention Research
Unit, London School of Hygiene and Tropical Medicine, London, United Kingdom, 3 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United
Kingdom, 4 Medical Research Council, Human Nutrition Research, Cambridge, United Kingdom
Funding: We would like to thank the A B S T R A C T
Medical Research Council for
funding this study. Background
Competing Interests: The authors
have declared that no competing Anaemia is a major cause of morbidity and mortality for children in Africa. The plasma
interests exist. protein haptoglobin (Hp) binds avidly to free haemoglobin released following malaria-induced
haemolysis. Haptoglobin polymorphisms result in proteins with altered haemoglobin-binding
Academic Editor: Stephen
Rogerson, Royal Melbourne Hospital, capacity and different antioxidant, iron-recycling, and immune functions. Previous studies
Australia examined the importance of haptoglobin polymorphism in m
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