substrate mediated enzyme prodrug therapy基质介导酶前体药物治疗.pdfVIP

Substrate Mediated Enzyme Prodrug Therapy 1 1,2 Betina Fejerskov , Alexander N. Zelikin * 1 Department of Chemistry, Aarhus University, Aarhus, Denmark, 2 iNano Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus, Denmark Abstract In this report, we detail Substrate Mediated Enzyme Prodrug Therapy (SMEPT) as a novel approach in drug delivery which relies on enzyme-functionalized cell culture substrates to achieve a localized conversion of benign prodrug(s) into active