sumoylation of dril1 directs its transcriptional activity towards leukocyte lineage-specific genessumoylation dril1指导其对白细胞lineage-specific基因转录活动.pdfVIP

SUMOylation of DRIL1 Directs Its Transcriptional Activity Towards Leukocyte Lineage-Specific Genes Alexandre Prieur.¤, Karim Nacerddine., Maarten van Lohuizen, Daniel S. Peeper* Department of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands Abstract DRIL1 is an ARID family transcription factor that can immortalize primary mouse fibroblasts, bypass RASV12-induced cellular senescence and collaborate with RASV12 or MYC in mediating oncogenic transformation. It also activates immunoglobulin heavy chain transcription and engages in hetero