statistical modeling of transcription factor binding affinities predicts regulatory interactions统计建模预测转录因子结合亲和力的监管作用.pdfVIP

Statistical Modeling of Transcription Factor Binding Affinities Predicts Regulatory Interactions Thomas Manke*, Helge G. Roider, Martin Vingron Max Planck Institute for Molecular Genetics, Berlin, Germany Abstract Recent experimental and theoretical efforts have highlighted the fact that binding of transcription factors to DNA can be more accurately described by continuous measures of their binding affinities, rather than a discrete description in terms of binding sites. While the binding affinities can be predicted from a physical model, it is often