原创力文档sumoylation regulates nuclear localization of lipin-1α in neuronal cellslipin-1αsumoylation调节核本地化的神经元细胞.pdfVIP
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sumoylation regulates nuclear localization of lipin-1α in neuronal cellslipin-1αsumoylation调节核本地化的神经元细胞
Sumoylation Regulates Nuclear Localization of Lipin-1a
in Neuronal Cells
Guang-Hui Liu*, Larry Gerace*
Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America
Abstract
Lipin-1 is a protein that has dual functions as a phosphatidic acid phosphohydrolase (PAP) and a nuclear transcriptional
coactivator. It remains unknown how the nuclear localization and coactivator functions of lipin-1 are regulated. Here, we
show that lipin-1 (including both the alpha and beta isoforms) is modified by sumoylation at two consensus sum
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