原创力文档telomeric position effect—a third silencing mechanism in eukaryotes端粒的位置这第三个沉默机制在真核生物.pdfVIP
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telomeric position effect—a third silencing mechanism in eukaryotes端粒的位置这第三个沉默机制在真核生物
Telomeric Position Effect—A Third Silencing Mechanism
in Eukaryotes
J. Greg Doheny, Randy Mottus, Thomas A. Grigliatti*
Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
Abstract
Eukaryotic chromosomes terminate in telomeres, complex nucleoprotein structures that are required for chromosome
integrity that are implicated in cellular senescence and cancer. The chromatin at the telomere is unique with characteristics
of both heterochromatin and euchromatin. The end of the chromosome is capped by a structure that prot
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