WntHedgehogNotchPathway抑制剂整理版.docVIP

Wnt inhibitors ICG-001 M.Wt: 548.63 Formula: C33H32N4O4 Solubility: DMSO ≥110mg/mL Water 1mg/mL Ethanol ≥45mg/mL Purity: 99% Storage: at -20℃ 2 years CAS No.: 780757-88-2 Biological Activity ICG-001 is a selective Wnt/β-catenin signalling inhibitor with an IC50 of 3μM. After selectively binding of ICG-001 to the NH2 terminus of cyclic AMP response element binding protein (CREB), ICG-001 prevented beta-catenin/TCF signaling. ICG-001 elevated the activities of caspase in colon carcinoma cell lines, but not normal cells via down regulation of survivin. It is exhibited that ICG-001 res