k+对心脏活动的影响（The effect of k+ on cardiac activity）.docVIP

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k+对心脏活动的影响（The effect of k+ on cardiac activity）.doc

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k对心脏活动的影响（Theeffectofkoncardiacactivity）

k+对心脏活动的影响（The effect of k+ on cardiac activity） 1. effects of K + on the heart activities: The overall view of myocardial extracellular K + sensitive concentration; but the sensitivity of myocardium is different, the most sensitive atrial, atrioventricular bundle - Purkinje system of low sensitivity of sinoatrial node. When the potassium concentration in the extracellular fluid increased, the effect on excitability was related to the increase of the concentration. When the K + concentration of mild or moderate increases, the concentration gradient of K + cells and K + decreased outflow weakened, resting potential (RP) of the absolute value decreases, and the threshold potential difference (TP) decreased, cell excitability increased; when the concentration of K + increased greatly, the absolute value of RP reduce (film - 55mV), reduce the sodium channel opening of sodium channel inactivation efficiency, gradually reduce or lose, excitability, serious, can lead to cardiac arrest in diastolic state. At this time, the action potential is formed only by the flow of Ca2 +, so the rising branch is small and slow, which slows the conduction speed and reduces the conductivity. When the concentration of extracellular K + increased, the permeability of the membrane to potassium increased, the ventricular repolarization process accelerated, the plateau shortened, and the refractory period shortened. High potassium has an inhibitory effect on myocardial contractile function. Because of the extracellular K + and Ca2 + in the cell membrane of competitive inhibition; so when the concentration of extracellular K + increased, the platform period flow of Ca2 + reduced intracellular Ca2 + concentration is increased, decreased Ca2 + excitation contraction coupling effect, thereby weakening the myocardial contraction ability. The 4 phase of automatic depolarization slows down, leading to a decrease in the sinus node automaticity and a decrease in heart rate. 2 the experiment showed that