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丙美卡因(Proxymetacaine)
丙美卡因(Proxymetacaine)
Proxymetacaine
[name of drug]
Generic name: Chinese proxymetacaine
English Name: Proxymetacaine
Other name: alcaine, alcaine, proparacaine, proparacaine hydrochloride, proxymetacaine, proparacaine hydrochloride, Ak-Taine, Alcaine, Diocaine, Proparacaine, Proparacaine, Hydrochloride, Proparacainum, Proxymetacaine Hydrochloride
[clinical application]
Surface anesthesia for ophthalmic * (7) * *, such as cataract surgery (6), the conjunctiva and corneal scraping, surgical suture and removal of foreign body, determination of intraocular pressure, three mirror inspection and other surface anesthesia operation. * (7).
[pharmacology]
1. pharmacodynamics, this medicine is ester surface anaesthetic. Its mechanism is to reduce the transient permeability of neurons to sodium, stabilize the nerve cell membrane, and prevent the generation and transmission of nerve electrical impulses, thus producing anesthesia. The first block pain fibers, then block warm, tactile and deep sensory fibers. The fine nerve fiber is more sensitive than the rough nerve fiber, and the recovery time is longer. * (5).
The anesthetic intensity of this medicine is slightly higher than that of tetracaine at the same concentration, and the action is quick. Because the structure is different from procaine and tetracaine, there is no cross allergy with other local anesthetics and very little initial irritation. * (1).
2. pharmacokinetics, 0.5% eye drops, 20 seconds after eye drops, anesthesia for 15 minutes. * (2).
[matters needing attention]
1. contraindications to this drug allergy. * (7).
With 2. (1) patients with hyperthyroidism. (7). (2) the patients with heart disease (7).
3. the safety and efficacy of drugs in children have not been established, but this drug can be used as a local anesthetic. * (5).
The 4. drugs on the impact of pregnancy pregnant women there is no domestic drug safety information. (7) the U. S. Food and Drug Administration (FDA) for classification of pregnancy saf
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