大鼠血管球囊成形术后血管局部纤连蛋白的改变（Changes of local fibronectin after balloon angioplasty in rats）.docVIP

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大鼠血管球囊成形术后血管局部纤连蛋白的改变（Changes of local fibronectin after balloon angioplasty in rats）.doc

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大鼠血管球囊成形术后血管局部纤连蛋白的改变（Changes of local fibronectin after balloon angioplasty in rats）

大鼠血管球囊成形术后血管局部纤连蛋白的改变（Changes of local fibronectin after balloon angioplasty in rats） Changes of local fibronectin after balloon angioplasty in rats 2010-09-07 Wu Yongquan, Wang Lihui, Hu Dayi Zhang Xiaofei, Zhang Wenjun, Lin Zhongxiang Abstract: Objective To investigate the role of extracellular matrix in restenosis after angioplasty. Methods the expression of fibronectin (Fn) and the expression of fibronectin (mRNA) at different time and position after injury were observed in rat thoracic aorta balloon injury model by immunohistochemistry and in situ hybridization. Results Fn began to express at third days after balloon injury, and increased further on day seventh. The 14 peak in Tianda and 30 days remained high in the middle of the neointima and near the intima. Conclusion the abnormal increase of Fn after balloon injury is an important cause of neointima formation, and may play an important role in the formation of restenosis after angioplasty. [Keywords] extracellular matrix, fibronectin, angioplasty, balloon Variation of fibronectin after balloon angioplasty in the rat thoracic aorta Wu Yongquan1, Wang Lihui, Hu Dayi2, et al. 1. Department of Cardiology, First Teaching Hospital, Beijing Medical University, Beijing Beijing Redcross Chaoyang 100034; 2. Hospital, Beijing 100020 [Abstract] Objective To investigate the function of extracellular matrix (ECM) on restenosis after balloon angioplasty. Methods The time and spatial course of mRNA and protein expression of fibronectin were exa-mined on the model of balloon angioplasty of the thoracic aorta in the rat with the combination of in situ hybridization and immunohistochemistry methods. Results The expression of fibronectin began at the third day after balloon injury and continued to increase at the seventh day, and reached the maximum from two weeks to one month after injury, which was most significance on the medial near basement membrance and neointima. Conclusion The variation of fibronectin may play a very i