玉屏补肾汤对冠心病患者高同型半胱氨酸血症影响研究.pdfVIP

中 文 摘 要 目 的：本实验旨在研究玉屏补肾汤对血清HCY的影响，同时观察对冠 心病心绞痛的临床疗效，试图为冠心病等血管性疾病的防治工作提供新 的方法与思路。 方 法：将广西中医学院附属瑞康医院老年干部病房 门诊及住院部 收治的冠心病患者 60 例,按其就诊顺序随机分为治疗组和对照组。对照 组按常规西药进行治疗，治疗组在常规西药的基础上加用玉屏补肾汤。 治疗中观察临床症状和体征，定期查12 导联心电图;服药前后做血、尿、 大便常规检查和肝肾功能检查;治疗前后测血浆同型半胱氨酸 （HCY)。 结 果： (1)治疗组治疗后血清 HCY 水平由 17.80 ±6.25umol/L 降至 14.39 ±2.66umol/L，较治疗前有显著改变(p0.05)，但与对照组比较无 明显差异(p0.05)。(2)治疗组心绞痛显效率为 36.67%，总有效率为 93.34%，优于对照组(p0.05);治疗后心绞痛发作频率和发作持续时间， 治疗组低于对照组，(p0.05)。(3)治疗组心电图显效率为16.67%，总有 效率为 60%，与对照组比较无明显差异(p0.05)。(4)治疗组中医证候显 效率为 30%，总有效率为93.33%，优于对照组(p0.05)。(5)对于中医证 候以及心绞痛分级属中度者，治疗组疗效皆优于对照组(p0.05)。(6)玉 屏补肾汤对人体血象、肝功、肾功无不良影响，试验过程中未见不良反 应。 结 论：通过该研究说明玉屏补肾汤合用西药治疗冠心病具有良好疗 效。玉屏补肾汤具有降低同型半胱氨酸的作用。 关键词：玉屏补肾汤；冠心病(coronary heart disease, CHD)；血浆 同型半胱氨酸(HCY) 1 CLINICAL STUDY ON THE EFFECTS OF YUPINGBUSHEN TANG IN TREATING HYPERHOMOCYSTEINEMIA AND ANGINA PECTORIS ABSTRACT Objective: This study was designed to study the serum Yupingbushen Tang HCY the impact of angina pectoris at the same time observe the clinical effect, an attempt to vascular diseases, such as coronary heart disease prevention and treatment work to provide new methods and ideas. Methods: Sixty patients with angina pectoris ，who were also differentiated as the type of kidney deficiency and blood stasis ，were selected and randomly divided into two group, therapy group and control group. In addition to same routine therapy to both groups, the former was administered folic acid, while the latter Yupingbushen Tang. The observation was made for changes of clinical features and signs serum HCY , routine test of blood, urine and shit, liver function and renal function were examined respectively before and after treatment. Results : （1 ）The serum level of HCY, in both group declined