多奈哌齐对急性一氧化碳中毒迟发性脑病患者认知功能的影响111丰改.docVIP

多奈哌齐对急性一氧化碳中毒迟发性脑病患者认知功能的影响 徐海波 赵琦 作者单位：浙江省衢州市柯城区人民医院神经内科，浙江省 衢州市 324000 通讯作者：徐海波，Email 【摘要】目的：观察多奈哌齐对急性一氧化碳中毒迟发性脑病(delyed encephalophthy after acute carbon monoxide poisoning,DEACMP)患者认知功能的影响。方法：将80例DEACMP患者随机分成对照组40例和治疗组40例。对照组给予常规药物、安慰剂加高压氧治疗，治疗组采用常规药物、高压氧加多奈哌齐5.0mg每晚一次，连续治疗90d为一疗程。治疗前和治疗后90d分别用简易智力量表（Mini-Mental State Exam，MMSE）及Barthel指数评定量表（BI）对患者的认知功能和日常生活能力进行评价，观察多奈哌齐对DEACMPA患者认知功能和日常生活能力的影响。结果：经90天治疗后，治疗组及对照组Barthel指数评分及MMSE评分均有所提高，病情好转，且治疗组更加明显，存在统计学显著差异。治疗后两组Barthel指数评分比较T=28.072 p=0.0010.05；两组 MMSE评分比较T=28.072 p=0.0010.05。结论：多奈哌齐对急性一氧化碳中毒迟发性脑病的治疗有一定优势。 【关键词】多奈哌齐；一氧化碳中毒；迟发性脑病 The Effection of Donepezil on Cognitive Function of Delayed Encephalophthy after Acute Carbon Monoxide Poisoning (DEACMP) Authors’unit: Peoples Hospital of Zhejiang Quzhou Kecheng District 【Abstract】 Objective: The affection of Donepezil on cognitive function of delayed ephalophthy after acute carbon monoxide poisoning (DEACMP) was studied. Methods: 80 cases of DEACMP were randomly divided into the control group of 40 cases and the experimental group of 40 cases. The control group was given treatment of regular medicine、placebo and hyperbaric oxygenation. The experimental group was given not only the same treatment as the control group but also the Donepezil 5.0mg once per night, and the experimental group was treated continuously for 90 days. The cognitive function of patients before and after the 90-days-treatment is evaluated respectively with Mini-Mental State Exam (MMSE) and Barthel Index rating scale. Results: The treatment of MMSE and BI score between the groups before and after treatment with statistical significance (P＜0.01，P＜0.05) and after the treatment MMSE and BI score was significantly higher than that in the control group, with significant difference（P＜0.01，P＜0.05）.Conclusion: Donepezil can greatly improve the cognitive and activity of daily living function of DEACMP patients. 【Key words】Donepezil, carbon monoxide poisoning, delayed encephalophthy，cogni