2型糖尿病患者外周血中SDF1水平及内皮祖细胞CXCR4表达率变化.docVIP

2型糖尿病患者外周血中SDF1水平及内皮祖细胞CXCR4表达率变化 　 作者：韦玉和, 罗春媛 周斌 冯小芬 【摘要】 目的： 探讨2型糖尿病(T2DM)患者外周血中基质细胞衍生因子1(SDF1)水平和内皮祖细胞(EPCs)表面SDF1受体CXCR4表达率的变化及意义。方法： 测定104例T2DM患者和26例健康对照者外周血中SDF1水平、EPCs数量和CXCR4表达率。糖尿病患者分单纯糖尿病组、血管病变组。结果： SDF1水平和EPCs数量对照组、单纯糖尿病组、血管病变组依次下降(Plt;0.05 或lt;0.01);CXCR4表达率单纯糖尿病组较对照组、血管病变组升高(Plt;0.05或lt;0.01)，血管病变组较对照组降低(Plt;0.05);SDF1水平与EPCs数量成正相关(r=0.241,Plt;0.05)。结论： T2DM患者外周血中SDF1/CXCR4轴与EPCs的数量及功能密切相关，参与血管病变的发生与发展。 【关键词】 2型糖尿病; 基质细胞衍生因子1; CXCR4; 内皮祖细胞 　　[Abstract] Objective: To study the changes of Serum level of Stromal cellderived factor1(SDF1) and expression of CXCR4 dwelling on the membrance of endothelial progenitor cells(EPCs)from peripheral blood in patients with type 2 diabetes mellitus(T2DM).Methods： To study the changes of Serum level of Stromal cellderived factor1(SDF1) and expression of CXCR4 dwelling on the membrance of endothelial progenitor cells(EPCs)from peripheral blood in patients with type 2 diabetes mellitus(T2DM). Results： The Serum level of SDF1 and the number of EPCs were decreased by degrees from the control to simple diabetic, or vascular complication groups(Plt;0.05 or 0.01). Compared with the control and vascular complication group, the positive rate of CXCR4 in the simple diabetic group was increased(Plt;0.05 or 0.01), which in the vascular complication group was lower than in the control group(Plt;0.05). There was a significantly positive correlation between the level of SDF1 and the number of EPCs(r=0.241,Plt;0.05). Conclusion： SDF1 and its receptors of CXCR4 in peripheral blood was closely related to the number and function of EPCs, and participated in the occurrence and development of vascular complications in patients with T2DM. 　　[Key words] type 2 diabetes mellitus;stromal cellderived factor1;CXCR4;endothelial progenitor cells 　　基质细胞衍生因子1(stromal cellderived factor1,SDF1)及其特异性受体CXCR4组成的SDF1/CXCR4轴在成熟或不成熟的造血祖细胞的动员、迁移及归巢过程中起重要作用[1]。2型糖尿病(type 2 diabetes mellitus, T2DM)患者内皮祖细胞(endothelial