云南白药对腰椎间盘突出病人手术出血量影响临床探究.docVIP

云南白药对腰椎间盘突出病人手术出血量影响临床探究 　【摘要】; 目的; 评价云南白药胶囊在腰椎间盘突出症后路开窗手术期的价值和安全性。; 采用随机、双盲、安慰剂对照临床。符合入选标准的60例患者随机接受云南白药胶囊0.5g或安慰剂，每日4次，共5天，比较两组患者的术中失血量和术后引流量，并对安全性进行评估。结果; 云南白药组术中失血量（275.17±140.79）ml，安慰剂组术中失血量（330.76±226.57）ml(Plt;0.057)，术后引流量两组间差异无显著性。结论; 口服云南白药胶囊可以明显减少腰椎间盘突出后路开窗手术中的失血量，安全有效。 ; ; 【关键词】; 云南白药;腰椎间盘突出症;手术 ; ; effect of Yunnan Baiyao capsule on perioperative bleeding of the patients undergoing prolapse of lumbar intervertebral disc on the clinic investigation 【Abstract】; Objective; To investigate the value and security of Yunnan Baiyao capsule on perioperative bleeding of the patients undergoing prolapse of lumbar intervertebral disc.Methods; A randomized double-blind placebo-control trial was conducted.60 patients were enrolled and randomized divided Yunnan Baiyao capsule group(500mg four times daily for 5 days) or placebo group.The amount of intraoperative and postoperative bleeding were compared，and the security of Yunnan Baiyao capsule was also analyzed.Results; Statistical analysis showed the amount of intraoperative bleeding were 275.17±140.79ml and 330.76±226.57ml(Plt;0.057) in Yunnan Baiyao capsule and placebo group，respectively，and there were no obviously discrimination in the amount of postoperative bleeding between two groups.Conclusion; Yunnan Baiyao capsule is effect and security on reducing the amount of intraoperative bleeding of prolapse of lumbar intervertebral disc. 毕业论文 ; ; 【Key words】; Yunnan Baiyao;prolapse of lumbar intervertebral disc;operation ; ; 本文选择60例腰椎间盘突出症后路开窗手术患者，采用随机、双盲接受云南白药胶囊和安慰剂治疗，比较病人手术出血量和安全性，报告如下。 ; ; 1; 资料与方法 ; ; 1.1; 一般资料; 本组60例，均为男性，年龄27～58岁，平均年龄42岁。均为腰4，5椎间盘突出症，其中19例合并有同一节段的椎管狭窄症。所有病人均无肝肾及凝血系统疾病，并排除有严重的原发性心脑血管及呼吸系统疾病。 ; ; 1.2; 方法; 采用双盲对照法。将60例病人随机分成两组，其中实验组30例，对照组30例。实验组术前4天起服用云南白药胶囊，对照组服用淀粉胶囊，每日4次，每次2粒。手术当日，术前2h服用2粒。在此过程中停用一切对凝血及出血量有的药物。对病人服药前、手术前、手术后的血色素、红细胞计数、血小板计数、出凝血时间、凝血酶原时间实行测定，记录并比较手术创口的出血量，对所有数据进行统计学。手术方法均采用一侧椎板开窗髓核摘除术，手术均由同一组医生进行，手术时间无明显差异。出血量测定采用纱布称重及吸引瓶出血量测术中出血量。麻醉方法均施行硬膜外麻醉。统计学方法为所测指标