代谢综合征患者胰岛素抵抗及炎症反应标记物相关性探究.docVIP

代谢综合征患者胰岛素抵抗及炎症反应标记物相关性探究 　【摘要】 目的 观察代谢综合征患者胰岛素抵抗(insulin resistance，IR)与血浆炎症反应标记物水平的关系，探讨炎症反应在代谢综合征患者胰岛素抵抗发生中的作用。方法 选择代谢综合征(metabolic syndrome,MS)患者31例，男19例，女12例，平均年龄(60.8±6.2)岁。正常健康对照20例，分别测定血浆高敏C反应蛋白(high-sensitivity C-reactive protein，Hs-CRP)、纤维蛋白原(fibrinogen，Fig)、空腹血糖(fasting blood glucose，FBG)、空腹血胰岛素(fasting insulin，FINS)和血脂等指标；计算胰岛素敏感指数(insulin sensitive index，ISI)。比较两组间空腹血浆炎症反应标记物水平的差异；并将空腹血浆高敏C反应蛋白、纤维蛋白原水平及MS的血脂参数分别与ISI作相关性分析。结果 代谢综合征组的ISI较正常健康对照组明显下降(P＜0.05)；血浆高敏C反应蛋白、纤维蛋白原水平等明显升高(P＜0.05)。多元线性回归显示:代谢综合征患者组高敏C反应蛋白、Fig、TG与ISI负相关(ｒ=-0.429，P＜0.01；ｒ=-0.312，P＜0.05；ｒ=-0.219，P＜0.05)。结论 （1）代谢综合征患者存在明显的胰岛素抵抗和血浆高敏C反应蛋白水平的异常。（2）慢性炎症状态可能是代谢综合征的特征之一。(3)炎症反应可能在代谢综合征患者胰岛素抵抗的发生中起了重要的作用。 【关键词】 代谢综合征；胰岛素抵抗；高敏C反应蛋白 Study on association of insulin resistance and inflammatory markers in patients with metabolic syndrome 【Abstract】 Objective To investigate the association of insulin resistance (IR) and inflammatory markers in patients with metabolic syndrome (MS)，and to explore the role of inflammatory markers in the development of IR in these patients. Methods 31 patients with MS were enrolled into study group，among of them，19 were male，and 12 were female，their average age was (60.8±6.2)y. The control group were made of 20 normal volunteers. The blood levels of high-sensitivity C-reactive protein (Hs-CRP)，fibrinogen (Fig)，fasting blood glucose (FBG)，fasting insulin，and plasma lipids were measured respectively in all the patients and normal subjects，and then，the insulin sensitive index was calculated. Differences of the levels of the fasting blood inflammatory markers between the two groups were compared，and the relative analyses between the Hs-CRP，Fig，blood lipid and ISI were made，respectively.Results Compared with the control group，the ISI of the MS group was significantly lower，but the levels of Hs-CRP and Fig were significantly higher. Multi-linear regression showed that，in MS group，the Hs-CRP，Fig，TG were inversely correlated with ISI，respectively(ｒ=-0.429，P＜0.01; ｒ=-0.312