a 2cm genome-wide scan of european holstein cattle affected by classical bse2厘米的全基因组扫描的欧洲荷斯坦牛受到古典疯牛病.pdfVIP

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a 2cm genome-wide scan of european holstein cattle affected by classical bse2厘米的全基因组扫描的欧洲荷斯坦牛受到古典疯牛病.pdf

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a 2cm genome-wide scan of european holstein cattle affected by classical bse2厘米的全基因组扫描的欧洲荷斯坦牛受到古典疯牛病

Murdoch et al. BMC Genetics 2010, 11:20 /1471-2156/11/20 RESEARCH ARTICLE Open Access A 2cM genome-wide scan of European Holstein cattle affected by classical BSE 1 2 3 1 4 Brenda M Murdoch , Michael L Clawson , William W Laegreid , Paul Stothard , Matthew Settles , 1,5 1 1 1* 6 Stephanie McKay , Aparna Prasad , Zhiquan Wang , Stephen S Moore , John L Williams Abstract Background: Classical bovine spongiform encephalopathy (BSE) is an acquired prion disease that is invariably fatal in cattle and has been implicated as a significant human health risk. Polymorphisms that alter the prion protein of sheep or humans have been associated with variations in transmissible spongiform encephalopathy susceptibility or resistance. In contrast, there is no strong evidence that non-synonymous mutations in the bovine prion gene (PRNP) are associated with classical BSE disease susceptibility. However, two bovine PRNP insertion/deletion polymorphisms, one within the promoter region and the other in intron 1, have been associated with susceptibility to classical BSE. These associations do not explain the full extent of BSE susceptibility, and loci outside of PRNP appear to be associated with disease incidence in some cattle populations. To test for associations with BSE susceptibility, we conducted a genome wide scan using a panel of 3,072 single nucleotide polymorphism (SNP) markers on 814 animals representing cases and control Holstein cattle from the United Kingdom BSE epidemic. Results: Two sets of BSE affected Holstein cattle were analyzed in this study, one set with known family relationships and the